The Powerpuff Girls are a group of puffed human girls that are the protagonists of the show of the name. They were accidentally created by Professor Utonium. The de feacto group members are Blossom, Bubbles and Buttercup. Blossom is the leader of the group, a level-headed and intelligent girl but also determined and strong. Bubbles is the cute and sensitive member of the trio, she is very kind and loves animals, but can get really furious when threatened and takes fighting seriously. Buttercup is a fun-loving tomboy, who doesn't plan and rather is all about action and hard fighting. During their adventures, the heroines clashed with deadly foes, including the ape mastermind Mojo Jojo, the androgynous devil Him, and the country bumpkin Fuzzy Lumpkins, as well as others, in order to save the city of Townsville from their clutches. The also appear in the second Heroes vs Villains war as one of the prominent heroes who make a stand against the forces of evil.
Heroes vs Villains War-Part Two
Vs Dr.Drakken
At the same time, the mad Doctor Drakken and his primary henchwoman, the formidable femme fatale Shego, had also broken into the museum to steal the Spear of Odin (which had been taken to the museum after the destruction of the Horned King's citadel). However, they were intercepted by the heroic Powerpuff Girls (Blossom, Bubbles, and Buttercup), who had been tipped off to the burglary, leaving the two to fight the Girls in order to obtain it. Though Drakken called upon his henchmen to battle them, the Girls overpowered them with ease. Angered, Drakken revealed several concealed guns, only for Bubbles to destroy them. Though Buttercup engaged Shego, she found she was a powerful adversary, though she managed to stagger her. During the fight, Odin (who had spent his time in hiding ever since his defeat by the Unicorn and the Medieval Warriors) arrived to take his spear back. While both the Girls and Drakken were focused on each other, Odin claimed the spear and reactivated its powers, preparing to unleash it on them all. At that moment, all the combatants from the previous bouts, including Littlefoot and his companions, Dumpty, Piltdown and his security guards, Darkwing, Clavious, Kim, and Ron, coincidentally gathered on the scene. In the confusion, Odin spotted Clavious, recognizing him from the time he served under the Horned King. Yet Clavious possessed the Eye of Odin, an artifact Odin yearned to take it for his own. Turning against his ally, Odin summoned the powers of the spear to blast at Clavious. While the blasts missed the sorcerer, they destroyed the museum's retaining walls instead, forcing all involved to retreat. Littlefoot and his friends managed to escape in the nick of time just as the museum imploded, though they lost the egg they retrieved.
Teaming with Kim and Ron
Meanwhile, Kim and Ron met up with the Powerpuff Girls, proposing to join forces to investigate the motives of their enemies.