Miss Simone Lenoir was a cat/human hybrid. She owned Moonscar Isle and, on every full moon, transformed into a were-cat.
First appearing in the animated film Scooby-Doo on Zombie Island, she also made an appearance in one of the fanmade submissions for the Disney vs. Non-Disney Villains war.
Disney vs. Non-Disney Villains War
Lady Tremaine attempted to recruit her onto team Frollo, but Simone refused. Transforming into her Were-Cat form, she attacked Tremaine only to be reduced to dust at the hands at the aristocrat's new magical powers.
Later her ghost appeared before her servant Lena instructing her to get revenge on Tremaine.
Non Disney Villains Tournament
Werecats and Weredogs
Both Lenoir and Anthony Romulus are invited to the house of Professor Moriarty on the night of the full moon. The professor is fully aware of the two's secrets, wishing to see which of them is more powerful. The two transform, both intent upon killing the other. However, Moriarty has his own designs, finishing off Romulus before Lenoir even needs to attack.
A Helpless Tool
Lenoir is perfectly content with Moriarty's decision to join up with the Legion of Darkness, a dark alliance headed by Dracula. She is less content when Moriarty and Dracula decide to use her soul as a gateway to the live-action universe. Despite her outrage, she is helpless as Dracula drains away her lifeforce, reducing her to a heap of ashes and bone.