Pinky and The Brain are two genetically-altered lab mice whom due to a gene-splicing incident, gained the ability of speech and thought. While Brain uses his incredible intellect to plot for world domination, Pinky enjoys the simple things of life like cheese, lint and fez hats. The two mice are recurring characters in Animaniacs and the main protagonist villains of it's spin-off series, Pinky and The Brain and Pinky, Elmyra and the Brain. The two are secondary players in the Non Disney Villains Tournament and Cartoon Villains War.
Non Disney Villains Tournament[]
Pest Control[]
Brain resolves to take over NIMH, only to be thwarted at every turn by Martin Brisby. Irritated by Martin's insanity, Brain decides to take matters into his own hands. He thus shoots and kills his opponent with a laser.
Friends and Enemies[]
Brain joins forces with Mojo Jojo, another animal experimented upon by Mok Swagger. The two, along with their other allies, scheme to topple Mok's dictatorial reign over the animals, with Brain serving as the chief inventor of the faction. After the murderous Scarface attempts to kill the Brain's ally, General Woundwort, the Brain deduces his foe's loyalties: Napoleon must have ordered the assassination. Brain teams up with Drake and another associate, Jenner, to take down some of Napoleon's allies: Cat R. Waul and Warren T. Rat. During the battle, Pinky fires some fireworks off at Warren T. Rat and his cats. Brain further frightens away Warren T. Rat and crew, leading Warren T. Rat to be murdered by Jenner. Cat R. Waul is also defeated, scoring the Brain and his allies a victory.
In the wake of their victory, Jenner and the Brain have a meeting with Dolf, Napoleon's new financial backer. There, Jenner convinces the Brain to turn traitor against Mojo Jojo and help Napoleon. While the Brain still believes in the cause of the animal revolution, he consents out of dislike for Mojo Jojo.
The Battle of Animal Farm[]
The Brain's hour of reckoning occurs during the Battle of Animal Farm, in which Mojo Jojo's forces attack Napoleon's. Though Jenner dies early in the battle, the Brain still decides to turn against Mojo Jojo. When the monkey transforms into a giant, the Brain uses his own size ray in order to even the odds. He punches Mojo Jojo right into a building, causing to topple on top of the monkey. The Brain thinks he has succeeded, but Mojo Jojo gets up. Furious, the monkey blows smoke right into the Brain's face. The Brain heads to the top of a large building, waiting for Mojo Jojo to climb up to him. While Mojo Jojo hurls his fury at the Brain, Carface and a surviving Cat R. Waul set off one of the Brain's lasers, knocking Mojo Jojo off the building to his death. The Brain returns to normal size, only to discover that Dolf has killed Napoleon and taken over Animal Farm. Thinking for his and Pinky's safety, the Brain allies with the treacherous crow.
Death of an Innocent[]
When Dolf comes to Pinky and the Brain with a request to join him in a secret location, the Brain desires to come along. Pinky, terrified of Dolf and his desires, implores Brain to stay put. Brain, wanting to keep his standing, rebuffs Pinky and hurts his feelings, feeling terribly guilty because of it. Pinky thus stays, letting Brain go with Dolf. In the middle of the meeting, Zero announces that he desires to take over Animal Farm. When Dolf refuses to back down, Zero blows up one of Dolf's laboratories, the very laboratory that Pinky is in. Brain is too late to stop his friend from being blown to smithereens.
Fury[]
Swearing vengeance upon all of humanity after Pinky's death, Brain grows erratic. He employs the mutation rays of Dolf's newest ally, Blackwolf, to transform a helpless scientist into an insectoid monster. Brain is later summoned by Rupee, as the turkey warns the Animal Farm's members, about Dolf's uprising and the danger he possess. However, Rupee is silenced by Cat R. Waul, as the evil cat imprisons him in Dolf's jail.
Non-Disney Villains Tournament Reboot[]
Vs Martin Brisby[]
The criminal mice known as Pinky and the Brain began to make their move as Brain decides it was time for him to advance and try to take over the NIMH rat colony, only to be thwarted by an insane Martin Brisby. The latter's insanity seemed to annoy Brain, and so, he became a nuisance that must be eliminated. Brain thus shot and killed his opponent with a laser.
Cartoon Villains War[]
Vs Mojo Jojo[]
Back in the Ice Kingdom, Mojo Jojo sought to create an army of intelligent animals with which to win the war. With this goal in mind, Mojo began experimenting on a pair of lab mice, granting them increased intelligence. However, the more intelligent of the two, dubbed 'the Brain’, refused to serve Mojo, having plans of his own. Together with his partner, Pinky, Brain escaped from his cage, much to Mojo's shock and fury. Brain then commandeered one of Mojo's laser cannons, blasting Mojo and knocking him into the lair's arsenal. However, as Brain celebrated his 'victory’, Mojo Jojo emerged, armed to the teeth. Mojo attacked Pinky and Brain, blasting them repeatedly. The two mice were forced to make a quick retreat, escaping the lab, while Mojo Jojo seethed in anger.
Vs Wilie E. Coyote[]
After escaping from Mojo Jojo, Pinky & The Brain establish their headquarters in a desert, when they notice an intelligent coyote menacing a roadrunner. Seeing an opportunity to gain notoriety, Brain decides to try to eliminate the coyote and rescue the bird. Will they succeed or will they merely end up as the coyote’s lunch?
Joining Skeletor[]
Hearing of the recent rise of Mojo Jojo, Pinky & The Brain begin looking to join a faction that can keep them alive during the war. Hearing of Skeletor’s recent successes, the two travel to New Snake Mountain and throw in their lot with him.
Prepared for the final battle[]
At New Snake Mountain, Skeletor holds a meeting of his own faction, planning to strike against Shredder before he can conquer the world. With the new power he has gained and the information Evil Lyn has given him, Skeletor and his allies prepare for a surprise attack on Shredder’s HQ in New York.
Cartoon Villains War - Part Two[]
On Skeletor's Meeting[]
Skeletor holds a meeting of his ruling council to discuss the current state of affairs, and to determine how best to proceed against their rivals. However, Megatron disagrees with Skeletor's planned course of action, and tensions begin to escalate between the two...
Vs XANA[]
Hoping to test his new weapon’s capabilities, Xanatos decides to send it to after the heads of Skeletor's Science & Research Division (the Brain, Dr. Mindbender, Tri-Klops, and Mindbender’s son.) Infecting the systems of the main lab, XANA begins turning the scientists’ very technology against them...
War of the Villains[]
Serving Mechanicles[]
In "War of the Villains", Both Pinky and The Brain were used as the power source to Mechanicles' latest invention to clean the deserts of Agrabah. Fed up by his mistreatment, Brain freed himself and Pinky from their cage to plot vengance on Mechanicles. While Pinky wondered how Brain would do it, Brain explained he would overpower Mechanicles' mechinizim. He was successful in his attempt and he and Pinky escaped as the vessel soared away into the sky.
Animated vs CGI Villains War (Saverio Gamba)[]
In Scar's faction[]
After Darkrai's assassination attempt, Scar recruits more animals including his saviours to defeat threats from another world.
Continuation plans[]
If the war didn't get rebooted, Pinky and the Brain's machines would have sent Darkrai,Shadow and Rouge the Bat.
Villains War (Legion of Darkness)[]
Villains Battles[]
Teaming with Scar[]
Scar was disappointed of Shere Khan and Kaa's failure against Nasty Canasta and Cottontail Smith. Then Pinky and the Brain arrive to help Scar and his alliance in taking out McLeach and his allies. Since the mice have got problems with McLeach and his poachers team, the lion recruits them for the final battle...
Vs Clayton Forces[]
Now, the battle between Scar's alliance and McLeach's alliance has begun. While Scar is chased by McLeach, Zira and her forces decide to take out the rest of McLeach's allies.
Vs Tyler[]
While searching for allies to help Scar, Pete and Yosemite Sam, Pinky and the Brain are attacked by Tyler, who was sent by Frollo to kill one of Pete and Yosemite Sam's allies in order to weaken their alliance. The mercenary's insanity annoys Brain, who decided to kill him...
Vs Forces of Hitler and Jan Valentine[]
Yosemite Sam, Scar and Pete send Cat R Waul and part of their forces to go and take out the Nazi Party, led by Hitler and Jan Valentine, who decided to attack Pete, Yosemite Sam and Scar from Frollo's orders. Cat R Waul and his forces (the Dazzlings, Shenzi, Banzai, Ed, Ratigan, Cruella, Pinky and the Brain) arrived to deal with the invaders. But can the group of Scar, Pete and Yosemite Sam's allies defeat the main forces of Frollo?
Bad news[]
With the Nazis and Frollo's guards dead, Pete, Scar and Yosemite Sam plot their final plan, however Brain bursts in, sad for Ratigan's death as he tells a terrible news. In fact...
Non Disney Villains War[]
Joining Yosemite Sam[]
After the downfall of Napoleon and after the demolition of the Animal Farm, Yosemite Sam recruits the bounty hunters Cottontail Smith and Nasty Canasta, the prince of Britannia, Lelouch vi Britannia (also known as the terrorist Zero), Pinky and the Brain. in order to weaken his enemy's alliance... Mojo Jojo.
New ally[]
While Yosemite Sam is dealing with the Dalton Brothers, Cat R Waul and his friends decide to wait for him and Claudandus (sent into a mission). However, they receive a visit from Sasha Scar, who is willing to help the shooter and his alliance in taking out Mojo Jojo and his alliance. As they welcome him in Sam's alliance.
TV Villains Tournament Remake[]
Animated Movies vs Cartoon Villains War[]
Disney vs Cartoon Villains War[]
Escaping Yzma[]
Yzma has decided to create new spells that she will test on her mice. However, one of the mice known as The Brain has already made an escape plan from the crazy woman.When Yzma was about to leave the lab,she saw the two mice escaping from their cage.Angered,Yzma tells Kronk to pull the lever that shall make the mice enter into their cage but Kronk accidentaly pressed the wrong lever.The Brain tells his partner, Pinky, the plan from escaping Yzma once again before she could came back after she was sent into the crocodile pit.Yzma then pressed another lever which made Yzma and Kronk to flee from the palace thus making Pinky and Brain to escape.
Joining Skeletor[]
After escaping from Yzma, Pinky and The Brain demanded to Skeletor as they agreed with the warlord's cause to kill The Horned King. Skeletor accepted them, but they fail they will suffer a fate worse than death.