Nuke York City is one of primary locations of the animated film, Rock and Rule. A homage to the real New York City, Nuke York is featured as amongst the new homes of the new civilizations of mutated street animals, after a nuclear eruption, that mutilated the human species alongside with Ohmtown, where it's inhabitants spend their casual lives, enjoying musical perfomances.
Regarding the villain tournaments, Nuke York City is displayed by the infamous Club 666, which appears as one of the minor, yet efficient, locations in Heroes vs. Villains War.