Dr. Neo Cortex is the main antagonist in the Crash Bandicoot video game franchise.

He has appeared in Animated Villains vs Video Game Villains, Disney vs Anime Villains, Worst Villain Tournament Ever and Video Game Villains War.

Disney Vs Anime Villains War

Vs Syndrome

When Emperor Zurg informs Syndrome of his plans for the invasion of the Multiverse, Cortex overhears this and decides to stop Syndrome once and for all. When the two meet, Cortex summons Galleom to take care of him. However, Syndrome soon drops an explosive onto Galleom destroying the robot. As Syndrome taunts him, Cortex breaks down and attempts to attack the "Super-Villain" himself. Unfortunately, Syndrome uses his powers to send Cortex flying across the air.

Disney Vs Anime Villains War - Part Two

Animated Vs Video Game Villains War

Video Game Villains War

Almost Killed

Cortex, along with the other villainous scientists of the war, resolves to gather his forces and take over the world. However, his plans are interrupted when Dark Samus breaks into his fortress. In a panic, Cortex summons Crunch to deal with the threat. Cortex makes his escape, though not before witnessing Crunch's death at Dark Samus's hands.

War By Proxy

It is revealed that Cortex has near total control of the global political underworld, as he is the creator of Boss Cass and various other villains stirring up local trouble. Cass serves as a liaison to Cortex, who focuses on the larger goals of the war. Cortex originally has the minor agent, Swampy, build a munitions factory to supply his forces, but the crocodile is killed when Baron Dante attacks. Cortex later has Arpeggio build a Clockwerk armor prototype, but both birds, mechanical and organic, are destroyed. Cass reports the successive stories to Cortex, who is reasonably enraged by the failures. He orders Cass to have the Fiendish Five wipe out the Boss Brigade of Erol, one of Ganondorf's top men. Though the Five succeed in taking out most of the Boss Brigade, Erol manages to finish off them all.

Animated Version of Dr. Neo Cortex single view in Worst Villain Tournament.

Worst Villain Tournament

Worst Hero and Villain War Ever

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