Villains who regularly or only fight Spider-Man in any form of their media, TV Show and Comic.
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Deadpool
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File:Dmitri Smerdyakov (Earth-194111).jpg
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Doctor Octopus
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Doombots
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Dormammu
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Dr. Doom
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Dragonfly
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M
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Madame Viper
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Maggia
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Man-Wolf
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Mephisto
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Mesmero
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Miriam The Queen of The Vampires
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Molten Man
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Morbius
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Mysterio
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Mysterio's Gargoyles
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P
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T
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The Green Goblin
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The Masters of Evil
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The Scorpion
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The Sentinel
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The Sinister Six
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The Spider-Slayer
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Tombstone
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Trapster
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