This category is about the villains who are pure evil and serious threats in this series.
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- Dai Shi
- Dark Bowser
- Dark Danny Phantom
- Dark Hulk
- Dark Samus
- Darkrai
- Darlene (Gravity Falls)
- Darth Sidious/Emperor Palpatine
- Deacon Frost
- Demyx
- Derek Powers
- Diablo (Diablo)
- Dick Hardly
- Dio Brando
- Doctor Emilia
- Doctor Octopus
- Doctor Robotnik/Eggman
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- Dolores Umbridge
- Donquixote Doflamingo
- Dormammu
- Dr. Deemo
- Dr. Destiny
- Dr. Hell
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- Dr. N. Tropy
- Dracula
- Drago Bludvist
- Dropkick
- Durza
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