Brain Drain are pills, that are used by the sinister ringmaster, Professor Screweyes, and the opposed material to Brain Grain pills. Unlike the latter, which can increase intelligence and smartness of any creature or human, or even a dinosaur, the Brain Drain pills act as the opposite method, as it would devolve the creature or the human into a primite and savage state. Featured as one of the prime materials from the animated movie, We're Back! A Dinosaur's Story, the Brain Drain pills are also featured in the events of Heroes vs. Villains War.
Heroes Vs Villains War
The Brain Drain pills are used in two instances. Once, when Professor Screweyes offers the Brain Drain pills to Tiana and Naveen, devolving them into frogs, and when Sarousch uses Screweyes' pills to devolve Louie and Cecilia into primitive monkeys, before reverting them back to normal, and then to devolve Rex's dinosaur gang, before they are rescued by the hero party.